| Name | Risk | Effect |
| Antidote | 0 | Removes 25 points poison |
| Beer | 0 | -1 PE for 1 min, +1 PE for 1min |
| Booze | 0 | -1 PE for 1 min, +1 PE for 1min |
| Buffout | 25% per dose | +2 ST +2 AG +3 EN for 6hrs; then -4 ST -4 AG -4 for 18hrs |
| Fruit | 0 | Restores some HP |
| Healing Powder | 0 | +8 HP to +18 HP and -2 PE for 36hrs |
| Jet | 50% per dose | +2 AP +1 ST +1 PE for 2days; then -2 AP -3 ST -3 PE for 2 days |
| Mentats | 33%-100% | +2 IN +2 PE +1 CH for 1 day; then -4 IN -4 PE -3 CH for 4 days |
| Mutated Fruit | 0 | +4HP +2Radiation for 6hrs |
| Nuka Cola | 10% per bottle | nothing |
| Psycho | 50% | +50% damage resistance -3 IN +3 AG for 4hrs; then +1 IN -3 AG -25% damage resistance; after 8hrs +2 IN -25% damage resistance |
| Rad-Away | 10% per dose | Removes 25 Radiation, -20 RadResistance for 10 days |
| Rad-X | 0 | +50% Radiation resistance for 1 day, then -25% 2 days in a row |
| Stimpak | 0 | Heals 5 to 20 HP |
| Super Stimpack | 0 | Heals up to 75 hp, but eventually lose 9 |
| Cheezy Poofs | 25% per box | Heals 5 to 10 HP |
| "Tragic" Cards* | 25% per game | -1 IN -2 PE -2 LK for 1 week |
| Name | Used For | Where to find |
| Bag* | Put stuff in it to help you organize your inventory. | Modoc Rat's Nest |
| Broc Flower | Combine with Xander Root and give to Hakunin in Arroyo to make Healing Powder | Lots of places. |
| Backpack* | Holds stuff to help you better organize your inventory. | ??? |
| Chrysalis Motors Highwayman | Travel faster on the World Map. (not really an item, but how else to classify it?) | Den |
| Doctor's Bag | Increases Doctor skill +25 when equipped | Broken Hills |
| Dynamite | In your inventory, Use to set timer, then drop to blow stuff up, unlock doors | Klamath Rat Caves |
| Easter Egg | Gives you a special friend. | New Reno Eldrige's Basement |
| Electronic Lock Pick | Boosts Lockpick skill +25 on high-tech locks | New Reno Eldrige's |
| Field Medic First Aid Kit | Increases First Aid skill when equipped | Abbey: Jack |
| First Aid Kit | Increases First Aid skill +25 when equipped | Klamath: Ardin |
| Flare | Use, then drop to increase the brightness in the immediate area | Klamath |
| Gas Mask | Prevents you from inhaling poisoned air. Put it in your active item slot. | EPA E2 |
| Geiger Counter | Use to see how irradiated you are | Vault City Courtyard |
| Jimmy Hat (Various colors) | Improves sexual performance, prevents pregnancy. Just needs to be in your inventory to work. | New Reno |
| Keys | Opens shed doors in the Entrance map of EPA | EPA: W1 Grounds Maintenance Director quest reward |
| Lockpick | Boosts Lockpick +25 skill on mechanical locks | GeckoSkeeter |
| Magic Eight Ball | With a high Luck, you'll get some good advice. | New Reno 2nd Street, Shark Club Level 2 |
| Monument Chunk | When consumed gives you +3 ST, +3 AG, +3 ?? temporarily | Big Head Special Encounter |
| Motion Sensor | Lets you see all critters on PipBoy map when equipped | Vault City Stark |
| Paramedic's Bag | Increases Doctor Skill when equipped | Abbey: Jack |
| Pip Boy Lingual Enhancer | Increases your Speech Skill | New Reno: Shark Club 3rd Floor |
| Pip Boy Medical Enhancer | Increases your Doctor Skill | New Reno: Shark Club 3rd Floor |
| Plastic Explosives | Same as Dynamite, but more powerful | Arroyo Temple of Trials |
| Radio | Listen in on enemy conversations in various places | Vault City Val's |
| Rope | Attach to a protrusion and descend. | Klamath |
| Security Room Key Card | Used to open doors in the EPA | EPA: W1 Security Director quest reward |
| Shovel | Dig up and cover graves or other mounds of dirt. | Arroyo Village |
| Stealth Boy | Increases Sneak Skill when equipped. Limited batteries. Useless in combat. | Random Encounter |
| Super Tool Kit | Boosts Repair skill +50 when equipped | Den Smitty |
| Tool | Boosts Repair skill +25 when equipped | Klamath Rat Caves |
| Water Flask | a.k.a. Vic's Water Flask. Has the number 13 printed on it. Prevents getting dehydrated in the desert. Consumed on use. | Arroyo |
| Xander Root | Combine with Broc Flower and give to Hakunin in Arroyo to make Healing Powder | Arroyo |
| Name | Used For | Where to find |
| Access Card | Allows access to the library's computers. | Abbey: Quest reward from Paul |
| Account Book | Take to Lynette in Vault City | Raiders: Barracks safe |
| Anna's Bones | Bury her in the grave marked "Anna Winslow." | Den |
| Anna's Gold Locket | Get it from Joey, then return it to her ghost. | Den |
| Bio-Med Gel | Used in the creation of Brainbot/Skynet | Sierra Army Depot Level 3 |
| Bishop's Holodisk | Take to Lynette in Vault City | New Reno: Shark Club 3rd Floor |
| Botany Holodisk | Give to Paul in the Abbey | EPA: E3 botany computer |
| A Bottle of Wine | New Reno: give it to Father Tully | Give a Lighter to Hank in the Basement of the Abbey |
| Brains | (Chimp, Human, Abnormal, or Cybernetic) Put in the RoboDog to get a new Party Member. | Sierra Army Depot |
| Cat's Paw Magazine | a.k.a. You Have No Idea - Collect 10 of these to give to Miss Kitty in New Reno | in many places |
| Cell Door Key | Broken Hills to free Jacob's friends in the jail. | Gotten from Jacob in Broken Hills |
| Computer Parts | Give to Tandi in NCR | Locker in Vault 15 Level 3 |
| Computer Voice Module | Repair the computer in Vault 13. | NCR |
| Coolant Report | Use the settings to cause the Gecko reactor to melt down. | Gecko |
| Cornelius' Gold Watch | Cornelius wants it back. | Modoc |
| Day Pass | Gets you into town during daytime hours. | Vault City |
| Doctor's Papers | Instructions for making your RoboDog Party Member. Merk in the Bazaar wants these, but you can buy them back. | NCR Downtown |
| Dog Tags | With all three (Tuco's, Blondie's, and Angel-Eyes's) in your inventory, open the safe. | Raiders: Barracks |
| Empty Jet Container | Show to Jagged Jimmy J. | New Reno: East Side Richard Wright's room |
| ERSI | Used in EPA when awakening one of the potential Party Members. | EPA E2, Chemie the computer |
| Excavator Chip | Give to either of the mine owners. | Redding |
| Eye | (Clifton's or Maxton's) Grants access to parts of the base. | Sierra Army Depot |
| Fake Citizenship Papers | Gets you into town regardless of time of day. | Vault City, bought from Skeev |
| Field Switch | Shuts down the air-purifier in the mine. | Broken Hills |
| Firewood | Fill Whiskey Bob's still, which is right next to it. | Klamath: Trapping Grounds |
| Flint | Get from Aunt Morlis and give to Mynoc at the bridge to get a Sharpened Spear. | Arroyo |
| Fuel Cell Regulator | Gets your Chrysalis Motors Highwayman running. | Gecko |
| Fuel Cell Regulator | Increases the efficiency of your Chrysalis Motors Highwayman | Klamath |
| G.E.C.K. | What your village needs to survive and thrive. | Vault 13, Enclave |
| Holy Hand Grenade | Kill the Vorpal-Rat | Special Encounter |
| Howitzer Shell | Use on the Howitzer to open the Depot Door. | Sierra Army Depot |
| Hydroelectric Magnetosphere Regulator | Use to repair the power plant at Gecko. | Vault City |
| Jet Antidote | Give to the doctor in Redding to rid the world of this drug. Use it on anyone to cure their addiction. | Vault City |
| Junk | Use on a generator in EPA to repair it. | EPA: Entrance |
| K-9 Motivator | Use on K-9 to get him to join your Party. | Navarro: Vertibird Workshop |
| Key Ring | Get from Don and free the slaves. | Slaver Camp |
| The Lavender Flower | a.k.a. "Becky's Book." Becky wants it back. | Den: Randomly in one of four places: 1) In the graveyard, just east of the church. 2) In the outhouse north of the Hole. 3) Behind a wall just southwest of the car behind Metzger's. 4) Beside a barrel south of the graveyard. |
| Metal Pole | At the Military Base, put one on the mine cart, then put some Explosives on it. At the EPA, use one on a vent on the Utility Level to get through. | Military Base Entrance on the ground south of the mine cart. EPA Entrance. |
| Mine parts | Use to repair the mine at Broken Hills. | New Reno: Renesco's |
| Moore's Briefcase | Deliver to John Bishop in New Reno | Vault City |
| Motor | Used in the creation of Brainbot/Skynet. Also to fix the water pump at the Abbey. | Sierra Army Depot, Vault City Courtyard |
| Mr. Nixon Doll | Give it to Curtis and he'll tell you where to get a Wrench | Vault City |
| Mutagenic Serum | Use to get your RoboDog Party Member from Doc Henry in NCR. | NCR |
| NavCom Parts | Use to get the ship in San Francisco moving | Vault 13 |
| NCR Spy Holodisk | Show to Tandi in NCR Council Hall | Vault 15 Level 3 |
| Note from Francis | Confront Francis, then show to Marcus in Broken Hills | Broken Hills Residential |
| Ode to the Flame Deluge | Abbey level 4, give it to Head Monk | Found on the body of Thomas in the Abbey Basement |
| Part Requisition Form | Get a part from the Gecko reactor supply room. | Gecko |
| Plasma Transformer | Skeeter in Gecko will trade one for a Super Tool Kit. | Jeremy in the Power Plant in Gecko will trade it for a Requisition Form. |
| Poison Tank | Replace Salvatore's regular tank with this one to kill him. | Basement of the Desperado in New Reno, southwest room. |
| Presidential Pass | Allows you in to see Carlson in his compound in NCR | NCR |
| Radscorpion Limbs | Show to Ma Buckner to prove the Dunton's guilt. | Klamath: Grazing Area, in the shack on the floor. |
| Ramirez Box | Take to Ramirez in The Stables | New Reno: Senior Mordino gives it to you to deliver. Don't open it. |
| Ranger's Map | Vortis in the Bazaar wants it. | NCR Downtown |
| Security Room Key Card | Opens up secured doors in EPA | EPA: Security Director Hologram |
| Sheriff's Badge | Shows folks you're working for the crippled Sheriff. You keep it as a reward, too. | Redding |
| Slag Message | Give to Jo in Modoc. | Ghost Farm: Vegeir in Caverns |
| Small Piece of Machinery | Give to Max in the Abbey Basement. | Abbey: Elaine on the 2nd floor. |
| Smitty's Meal | Mom wants you to deliver it to Smitty. | Den: West Side |
| Survey Map | Puts San Francisco on your PipBoy | Military Base: Entrance |
| Talisman | Talk to the Brain in Gecko to convince him to stop his molerat raids on Vault City. | Ask Connar in Vault Village for it while trying to solve the molerat problem. |
| Temple Key | Steal it from Cameron to unlock the door behind him. | Arroyo: Temple of Trials |
| Trapper Town Key | Open the door in Trapper Town. | Give any type of Meat to the dog in Klamath Downtown to get it. |
| Vic's Radio | Give it to Vic in The Den to help free him. | Klamath |
| Vault 15 Key Card | Use on the door to Vault 15. | Zeke at Vault 15: A squatter gives it to you to get into the Vault. |
| Vault 15 Shack Key | Open the door to set Chrissy free. | Talk the guard in Vault 15: East Entrance into not dying and he'll give it to you. |
| Westin Holodisk | Give to Lynette in Vault City | NCR: Westin. |
Books are found in far too many places to list them all.
Books
| Name | Effect |
| Big Book of Science | Increases Science Skill |
| Cat's Paw Issue #5 | Increases Energy Weapons skill by +5 |
| Dean's Electronics | Increases Repair Skill |
| First Aid Book | Increases First Aid Skill |
| Guns and Bullets | Increases Small Guns Skill |
| Scout Handbook | Increases Outdoorsman Skill |
| Name | Effect | Where to find |
| Bishop's Holodisk | Contains evidence that Bishop is behind the raids on Vault City | Bishop's safe in New Reno. Give it to Lynette in Vault City. |
| Broadcast Holodisk | News reports of events leading up to the war. | Sierra Army Depot Level 3 |
| Evacuation Holodisk | General Clifton orders an evacuation. | Sierra Army Depot Level 1 |
| Experiment Holodisk | Dr. H. Lector's personal diary. | Sierra Army Depot Level 4 |
| Hubologist Holodisk | The history and beliefs of Hubology. | San Francisco Hubologist Base |
| M.B. Holodisk 1 | Captain Pickard reports his status. | Military Base Level 1 |
| M.B. Holodisk 3 | Sergeant Bracks reports in. | Military Base Level 3 |
| M.B. Holodisk 4 | Report by an Enclave official about the progress of the excavation. | Military Base Level 4 |
| M.B. Holodisk 5 | Colonel Sanders gets a sample of the FEV. | Military Base Entrance |
| Medical Holodisk | Corporal Dixon's injury report. | Sierra Army Depot Level 1 |
| Vault 13 Holodisk | Puts a place on your map called "Fake Vault 13." | Merk can sell it to you in NCR Bazaar |
Useless Stuff
You may safely sell all of these.
| Name | Notes |
| Ball Gag | |
| Bottle of Shampoo | |
| Box of Noodles | |
| Boxing Gloves | |
| Bug Spray | |
| Cosmetics Case | |
| Dice | |
| Drill | Found at the EPA Entrance. |
| Dog Food | |
| Drugs | Found at the EPA Entrance. The Q&A hologram on E1 can identify it as cannabis. |
| Empty Hypodermic | |
| EPA Pamphlet | Read it, then sell it |
| Expired GECK | Did the Hubologists actually use this thing? If so, where? |
| Flower | |
| Fuzzy Painting | |
| Gecko Pelt | |
| Golden Gecko Pelt | worth more than the grey version |
| Hypodermic Needle | |
| Hintbook | crashes the game if you try to use it |
| Iguana-on-a-stick | |
| Lighter | |
| Meat Jerky | |
| Old Coin | It says "unknown face" but it looks like Susan B. Anthony, to me. |
| Pack of Cigarettes | |
| Plant Spray | |
| Pop Rocks | |
| Ranger Pin | Quest reward that shows everyone you're a Ranger. |
| Syringe | |
| Scorpion Tail | |
| Small Piece of Machinery | |
| Test Tube Rack | |
| A Watch | Your PipBoy is way cooler. |
| Water Chip | Ironically, there are hundreds of these. |
| Yellow Reactor Keycard |
last modified 28 February 2026